Blog Arasys Perfector - Xanya Sofra Weiss

Xanya Sofra-Weiss. Ph.D, (2008)

Ionic Currents: The Spark of Life and Directional Force in Cellular Metabolism and Energetics.

The aging process cannot be conceptualized by examining a single gene or a single pathway, but can best be addressed at the systems level. Aging is not only the sum total of shortened telomeres, denatured proteins and DNA molecules, or oxidative damage in the mitochondria. Aging attacks key regulatory nodes crucial for the biological network stability. It is the dynamic process of increasing imbalances in the systemic organization of degenerating biological processes. DNA and stem cells engineering have successfully reversed certain individual components of time attrition resulting in rejuvenation and aging delay. So far, research has merely followed a sequential process that goes from the part to the whole, identifying aging genes and engineering stem cells, etc. However, discovering pieces of the puzzle still requires identification of the interconnections between matching pieces before the solution emerges. The old, the ill, and the injured all suffer from misarranged patterns of atoms. A single substitution an A for a G in a DNA molecule can cause a significant change in the conductance of the molecule leading to cancer. Such research findings demonstrate how the sequence and interrelations of amino acids in a protein, or the sequence of base pairs in a DNA molecule can become determining factors between health and disease, aging and youth. Gene expression is stronger when the gene is attached to the nuclear envelope (the membrane that surrounds the nucleus) than when it moves away from the nuclear envelope (see image). In other words, cells make use of the nuclear architecture to code epigenetic information. The DNA sequence alone doesn’t determine everything. The importance of the spatial organization or nuclear architecture in regulating gene expression begs for scientific observation that does not merely focus on the study of atoms and molecules, (the basic components of a Gestalt); but on the interrelations, sequence, orientation and spatial organization of these atoms and molecules (the dynamic whole or Gestalt). Recent research has shown that DNA, proteins, cells, including stem cells, appear to be electrical in that they demonstrate conductivity or the presence of ionic currents. Since electricity is a dynamic entity emerging out of the interactions of atoms and molecules, we propose that perhaps the simplest way of focusing on the entire system is by decoding the complex electrical signals that map biological interactions with respect to spatial organization. Biological signals must be analyzed in terms of their amperage, frequency, voltage, interactions, orientation, spatial organization. Next will be their translation into electronic signals that comply with the specifications of amperage, frequency, voltage or biological signals. Electronic signals will then be intertwined to orchestrate a Gestalt waveform built on the basis of information attained from observations of biological interactions and architecture – a process similar to that done in Pollock’s lab (1990-2004). This Gestalt waveform will act as an electronic diplomat to awaken biological processes that have diminished with aging or disease by signaling the recuperation and activation of biological reparative mechanisms leading to extended longevity.

Xanya Sofra-Weiss, Ph.D & Ali Mohamed, M.D.

Individual phenotypic differences result in a variation of T4 to Free T3 conversion. Free T3 stimulates lipolysis. This leads to polymorphic and individualized lipid deposition patterns. Hyperthyroidism is associated with weight loss via an increase in metabolic rate and lipolysis. Hypothyroidism, on the other hand, is associated with weight gain via a decrease in metabolic rate.

A literature review by Guillermo et al (2003) has shown that the risk of thyroid dysfunction in Diabetic patients is two- to threefold higher than in the general population. A number of studies have shown that thyroid hormones represented by serum total T3 and T4 concentrations and serum Free T3 and T4 concentrations were significantly lower in obese non-insulin-dependent diabetics than control subjects. Low T3 is also a strong predictor of mortality in cardiac patients and may be directly implicated in the poor prognosis of cardiac patients.

The biological functions of GF (GH) are carried out by Insulin-like Growth Factor 1 (IGF-1). IGF-1 is the key determinant of somatic growth. It regulates puberty and gonadal function, and influences body composition as well as structural and functional maintenance of adult tissues. Loss of skeletal muscle mass, increased adiposity, and other unwelcome accompaniments of aging have been linked to age-related decline in pituitary GF secretion. On this basis, administration of GH is often advocated as an “anti-aging” therapy. However, administration of GF has a number of adverse side effects such as Diabetes, Carpal Tunnel Syndrome, joint and muscle pain, fluid retention, High Blood Pressure, etc. (Hintz, 2004). In addition, mutant GF deficient animals have demonstrated prolonged longevity (Corpas et al, 1993). Recent research in humans (Hoeijmakers et al, 2008) has shown that GF and IGF-1 may be associated with aging as a result of the system’s tendency to focus on growth, which diminishes its capacity to invest in maintenance and repair, i.e. “the survival response.”

Xanya Sofra-Weiss

Aging is not just the sum total of individually deteriorating cells, shortened telomeres, denatured proteins and DNA molecules, or oxidative damage in the mitochondria. Aging is the dynamic process of increasing imbalances caused by: (1) cellular energy shortage, (2) incomplete cellular differentiation, (3) immune deficiency, (4) decreased systemic intelligence reflected in a/ defects in repair mechanisms, b/ inadequate spatial orientation and c/ poor network communication. International research has repeatedly shown that: (1)Electrons stabilize free radicals (2) Electron transport within DNA deflects oxidative damage; (3)Electrons provide a) direction information b) embryonic development c) cellular differentiation d) healing.(4) Electron transport chain results in Protons spinning the ATP-synthase in the mitochondria to produce ATP. Additionally, Proteins, the central intelligence mechanism of the cell are synthesized by aminoacids that are bound by virtue of their electric charge. A number of studies have shown that Protein synthesis occurs at specific frequencies below 1 Hz. Modern electronics and molecular biology research are combined to deduce the specifications for a technology that promotes Healthy Anti-aging. Resonating the firings, spatial organization and rhythms of electrically excitable cells leads to healing and rejuvenation in a completely safe, noninvasive method. However, to date, few devices pay attention to waveform formation that reflects the essence of cellular communications. There is a lot to be gained by developing a device that can emit signals capable of intertwining with those of signal transduction receptors (including G proteins, gene transcription and the activation of T cells). Such a device will not only become the protagonist in Anti-aging but it will have sufficient sophistication to heal disease and enhance overall immune efficiency.

Xanya Sofra-Weiss, Ph.D

Modern electronics and molecular biology research are combined to deduce the specifications for a technology that promotes Healthy Anti-aging. Resonating the firings, spatial organization and rhythms of electrically excitable cells leads to healing and rejuvenation in a completely safe, noninvasive method. The pervasive presence of ionic currents in core biological functions: (1) signal transduction, (2) the electrical conductivity of DNA, (3) the electromagnetic dynamics of protein conformation, render nanoelectricity the common denominator of all integral parts composing the Gestalt of a living organism. However, to date, few devices pay attention to waveform formation that reflects the essence of cellular communications. A simple square waveform is too impoverished to resonate the harmonious complexity of a biological system, the way a two piece band is insufficient in delivering the musical richness of a symphony. The waveform is as important in cellular resonance as language is in verbal communication. Language is confined by grammar and syntax rules in order to convey a message correctly. Similarly, a waveform is confined by the spatial organization and rhythm of endogenous electrical signals that cells use in their multifaceted networking. Ion resonance has a harmonic specificity that has to be encompassed before a device is designed. There is a lot to be gained by developing a device that can emit signals capable of inter twining with those of signal transduction receptors (including G proteins, gene transcription and the activation of T cells). Such a device will not only become the protagonist in Anti-aging but it will have sufficient sophistication to heal disease and enhance overall immune efficiency

To follow up on the calorie restriction research noted today at the Longevity Meme, here is more of the same: A number of studies have shown that restricting calories increases the lifespan of animals, but the biological basis for this has remained elusive. A new report hints that growth hormone, as well as insulin, are key factors in the life-extending effects of calorie restriction. “The implication for pharmaceutical development would be that the signaling pathways of growth hormone and insulin may be logical targets for development of anti-aging medicine”
Bartke’s team tested whether growth hormone and insulin are tied to the life-extending effects of calorie restriction in a series of experiments with normal mice and mutant mice deficient in growth hormone. The mutant mice do not express the receptor for growth hormone (and are therefore growth hormone resistant), have profoundly suppressed insulin levels, and are known to live longer and age more slowly than normal mice … in sharp contrast to its effects in normal mice, calorie restriction failed to increase lifespan in mutant mice lacking growth hormone receptor.
Although it would be irresponsible to recommend that healthy people start using anti-diabetic drugs,” said Bartke, “it is reasonable to suggest that treatment(s) causing an improvement in insulin sensitivity combined with modest reduction in insulin release would reduce risk of age-related disease and likely also delay aging. Most interesting. Calorie restriction researchers are pulling at strands of the tangled knot of metabolic biochemistry - everything affects everything else. It is possible that an extra decade or two of healthy life span for even the most healthy and long-lived amongst us could result from present research into the biochemistry of calorie restriction. It’s also possible that nothing of the sort will materialize prior to this line of research being rendered obsolete by the advance of much more aggressive approaches to tackling aging. It seems to me that metabolic research cannot be more than a stepping stone to far better ways of extending the healthy human life span. Scientists should already be striding beyond these studies to tackle the repair of age-related damage in a more direct manner.

Every organ and cell in the human body uses
ionic currents in the performance of critical daily
functions. Electricity is the common denominator
of all parts composing the Gestalt of a living
organism. Except that the electricity it takes to
run a cell is so miniscule that it is estimated to
be below the nano ampere range- i.e. less than
one over a billion of an ampere (Neher, Nobel
Prize 1991). Every cell generates a voltage of
roughly 70 mV (millivolt — one thousandth of
a volt) across its outer membrane, which is used
for a variety of signaling and transport functions
(R. Nuccitelli, 2003). Many organ functions are
coordinated with electrical signals, such as the
wave of depolarisation that sweeps over the heart
to trigger a synchronous contraction to pump
blood efficiently. Abnormalities in this electrical
signal can lead to fibrillation and heart attacks.
The voltages generated by the contracting heart
are so large that they can be easily detected at
the surface of the body and this signal, called the
electrocardiogram or EKG, is routinely used to
diagnose heart disease. With this abundant use
of electrical signals in cellular and organ function,
it should not be a surprise that endogenous electric
fields are also important for normal development,
cellular regeneration and wound healing.
Endogenous wound electric fields were determined
first more than 150 years ago by the German
physiologist Emil Du-Bois Reymond. Such
electric fields have been shown to exist naturally
at the site of a lesion. Several recent experiments
support a role for electric fields in the stimulation
of wound healing in the developing frog neurula,
and adult mammalian cornea. Some experiments
indicate that when the electric field is removed
the wound healing rate is 25% slower. In addition,
nearly every clinical trial using electric fields to
stimulate healing in mammalian wounds reports a
significant increase in the rate of healing from 13
to 50% (Nuccitelli, 2003). Nucciteli (2003) studied
electric fields in embryos during development,
regeneration and wound healing. He found that
all embryos that were investigated drive ionic currents
through themselves and these currents will
generate internal electric fields.
ELECTRICAL CONDUCTIVITY OF PROTEINS
Transport of ions through biological membranes requires
special channel proteins. One specific channel protein,
ATPase, uses up as much energy as it creates, turning the
cell into a constantly recharging biological battery.
The contour of a protein backbone that determines its
shape is largely determined by the interaction of electromagnetic
charges among the linked amino acids. Most
amino acids have positive and negative charges which act
like magnets. The final shape, or conformation of a protein
reflects a balanced state among its electromagnetic
charges. The distribution of the electromagnetic charge
within a protein, and therefore its shape, can be altered by
electromagnetic fields or electric signals coming in from
the organism’s environment. Protein assemblies are responsible
for functions such as respiration, digestion,
muscle contraction and the energy generating Krebs cycle.
Cells use the movements of protein assemblies to empower
specific metabolic and other biological functions. The
constant shape-shifting movements of proteins, which
can occur thousands of times in a single second, are the
movements that propel life.
ELECTRIC DNA
Many researchers have attempted to measure the electrical
conductivity of DNA. However, it is very difficult to
control all the parameters that may affect the conductivity
of DNA, e.g., length, conformation, ionic environment,
humidity, experimental protocols, and many other factors.
Inomata et al (2007) measured the electrical conductivity
of DNA using fine electrodes with a gap of about 200
nanometers and found that DNA contained both conducting
and insulating parts. Electrical conduction in
DNA appeared to be temperature dependent.
DRUG FREE THERAPY FOR SKIN TUMORS
Nucciteli et al (2006) discovered a new, drug-free
therapy for treating solid skin tumors. Pulsed
electric fields greater than 20kV/cm (1,000 volts
per centimeter) with rise times of 30 nanoseconds
and durations of 300 nanoseconds penetrate into
the interior of tumor cells and cause tumor cell
nuclei to rapidly shrink and tumor blood flow to
stop. Melanomas shrink by 90% within two weeks.
INACTIVATING THE AIDS VIRUS
In March 1991, William D. Lyman and his colleagues
at the Albert Einstein College of Medicine found
that treatment durations as short as 6 minutes substantially
incapacitated the AIDS virus, halting its
ability to reproduce. In this study, 10 microliters
of HIV-1 infected blood containing 105 infectious
particles per ml were exposed to an electric current
passing between two platinum electrodes placed in
direct contact with blood in vitro. Currents ranged
from 25 to 100 microamperes and exposure times
ranged up to 12 minutes. Exposing the virus to direct
electric current suppressed its capacity to induce
the formation of syncytia, an indicator that
quantifies the production of infectious particles.
Passing 25 microamperes for 8 minutes through the
blood reduced the number of syncytia from 50 to
65% while a charge of 50 microamps for 6 minutes
through the blood reduced the number of syncytia
by 90%; Also reverse transcriptase assay, an index
of viral protein production, was found to be negatively
impacted. Reverse transcriptase activity was
almost totally ablated (reduced by 94%) with an
exposure to 100 microamps for 6 minutes. Steven
Kaali (1992) reported that in addition to inactivating
the AIDS virus, this microcurrent treatment
also left the patients’ blood samples free of hepatitis.
The blood cells themselves were unharmed by
the treatment. COMPLEX SQUARE WAVEFORM
THE LANGUAGE OF CELLS
Communication systems are based on the serial order
of signs and symbols. This organization is evidenced
in language in the form of syntax and word morphology.
Waveform formation is for electrical configurations
what syntax is for verbal communication. While
studying single channel ion currents, Neher (Nobel
Lecture, 1991) reported “blimps which resembled
square pulses” reflecting “signals of biological significance.”
(See below)
Square waveform electrical currents are known to be
effective for promoting healing and anti-aging (Pollock,
2007). A complex square waveform is formed
out of several sine waveforms. Sine waveform is the
shape of an ideal alternating electrical signal and results
from the voltage smoothly increasing from the
negative maximum to the positive maximum and back
again.
A simple square waveform is fairy inexpensive and is
the result of the voltage shifting rather abruptly from
negative to positive. Unlike the simple square waveform,
a sine waveform requires fairly expensive components.
A device that combines several sine waveforms composing
what is termed a “complex square waveform” will be admittedly
the product of diligent work and great expense. A complex
square waveform, however, will be necessary to provide
a high definition signal that can resonate and become assimilated
by the intricate network of biological communications.
An example of such a biological signal is the Hippocampal
Place cells (O’keefe, 1976; 1978; 2007). These cells are the
principal cells in each of the layers that fire in complex bursts
in the Hippocampus, every time an animal is moving.
Inside its firing-field (i.e. the region in which a cell fires the
most), a place cell may have a maximum rate of 20Hz or
more, whereas outside its firing-field, a place cell may fire less
than 0.1 Hz. The above waveform of the place cell’s pattern
of firing could be resonated by the complex square waveform
emitted by an electronic device. Resonance, however, would
occur only if the device’s complex square waveform was
composed by sine frequencies ranging from 0.1Hz to 20 Hz
combined to reflect the firing pattern of place cells. A complex
square waveform is made out of a minimum of five sine
frequencies. A signal that demonstrates a certain degree of
clarity requires a waveform that is made out of at least 60-100
of sine waveforms. Every added sine waveform, however, increases
the expense of the electronic apparatus, which is why
most manufacturer’s avoid building shaped waveforms out
of sine waves. The difference between a simple square waveform
and a complex square waveform made out of sine frequencies
is respectively equivalent to virtual memory versus
RAM, or Morse code versus the telephone. Both types of
waveforms may appear identical in an oscilloscope. However,
the least difference inspected by an oscilloscope may trigger
an unwanted response within the organism. That unwanted
response is most often an aspect of biological resistance, a
shutting of the door to the foreign agent that has triggered
a automatic biological safety mechanism. Even in the case
when an outside signal is rendered benign by the organism’s
cellular defences, communication between a simple square
waveform and a biological signal will be as futile as trying to
exchange opinions with a “talking toy” that invariably repeats
itself over and over. Due to unsurpassed limitations in communication,
the organism will soon discard the simple square
waveform signal and the results provided by the device may
end up clinically mediocre and short lasting.
COMPLEX SQUARE WAVEFORM:
HANDMADE DEVICES
After seventeen years of research the coinventor of the
Pacemaker (Pollock, 1990; 1993; 1996; 2004; 2005;
2006; 2008) developed the Arasys. The Arasys emits
an analogue complex square waveform composed out
of up to 1,000 sine frequencies. In 2008, the Pacemaker
co-inventors engineered the Ion Magnum that
emits an even more complex analogue waveform than
the Arasys. Arasys and Ion Magnum analogue complex
square waveform has been proven useful in treating
muscle atrophy and nerve wasting conditions such
a Multiple Sclerosis. In these conditions, myelinforming
glial cells which wrap around nerve fibres are
compromised by the disease. Speed and intensity of
neuronal signals over long distances deteriorate. The
brain does not replace these myelin-forming glial cells
very effectively because the communication between
neuron and brain has been interrupted. Therefore,
the brain has hardly any access to these neuron cells.
Here is a situation where a complex square waveform
could substitute the weak or absent neuronal
signals travelling from the neuron to the brain. Such
a waveform would be successful in completing the
mission provided that its complexity had the clarity
and communication capacity of a naturally occurring
neuronal signal that would allow it to unlock all kinds of biological
gates, whispering the required passwords. The reason
why Pollock’s complex square waveform has had dramatic,
long lasting and irreversible results in body building, in
helping muscle wasting conditions, and in several anti-aging
treatments, is (1) building the waveform on the basis of diligent
research on neuron-firing signals and (2) the handmade
composition of this waveform that surpasses any computerized
program. Apart from muscle building, neuronal signal
restoration and enhancement, as well as acting as an antioxidant,
the Arasys Perfector and Ion Magnum signal offers a
significant increase in blood circulation and lymphatic drainage
than leaves the body with an overall sense of increased
health and wellbeing. Arasys Perfector and Ion Magnum
specifications and waveforms were formulated on the basis
of two decades of research. Why is it that these devices cannot
be duplicated? Because as Gerry Pollock, coinventor of
the pacemaker, stated, “when you copy something from the
outside, you do not know how or why it was created.” A
biological system has the instinctual sensitivity or cellular
intelligence to distinguish between nourishment and harmful
agents or between malevolent bacteria and bacteria that
are necessary for certain biological functions– e.g. digestion.
Every cell is empowered with intelligence that helps it nourish
and protect itself against any danger. In the absence of
cellular intelligence all types of viruses and parasites would
enter and take over an organism and all life would be abolished
a few hours after birth. A simple square waveform is
too impoverished to resonate the harmonious complexity of
a biological system, the way a two piece band is insufficient
in delivering the musical richness of a symphony. It would
be unrealistic to expect a large audience in a symphony performed
by only two instruments and it would be even more
unrealistic to expect a big applause. Similarly, not too many
cells will respond to the impoverished simple square waveform
that is striving to deliver the timbre of a complex signal
in a rough, sketchy fashion to minimize the project expense.
Such simple square waveform will most likely be experienced
by the biological system like a static radio station or an incomprehensible
telegram missing a few words. The waveform
composition is the most crucial factor in turning an electronic
device into a communication system emitting signals that
become assimilated by a biological organism, thus enhancing
or completing significant life functions. The waveform
is as important in cellular resonance as language is in verbal
communication. Language is confined by grammar and syntax
rules in order to convey a message correctly. Similarly, a
waveform is restricted by the specific sequence of a multiplicity
of sine waveforms composing the necessary signal to resonate
and spatial organization of endogenous electrical signals
that cells use in their multifaceted networking. Ion Magnum,
Arasys and Perfector are designed to resonate the communication
signals of the biological organism within the intricate
spatial organization and rhythm of electrically excitable cells,
to produce results similar to those resulting from the reparative
capacities of the body in its ideal state of existence where
age is not a factor.
© 2008 Xanya Sofra-Weiss, Ph.D
Ion Magnum, Arasys, Perfector Research
www.arasysperfector.com

Rapid and Efficient Erythrocyte Separation by
Ionic Pacemaker Technology for the Skeletal Muscle

Xanya Sofra-Weiss, Ph.D

ABSTRACT

The complexity of aging mechanisms demands a research platform with a systems-level view capable of meeting the multidimensional manifestation of self-disorganizing, self- repairing life processes.  Our research is based on neuro-resonance signaling technology that acts as an ambassador to the vast intelligence network of the nervous system.  A neuro-resonant “ambassador” is necessary considering the abundance of unknown immune functions and resistances within the body that will a) eliminate any signals or agents inconsistent with the overall neurocommunications; b) lead to a negative feedback loop mechanism that will inhibit self repairing processes. This technology was originally developed for the smooth heart muscle by the inventors of the pacemaker.  One of the pacemaker co-inventors, Gerry Pollock extended the knowledge accumulated from the smooth muscle to the motor nerves of the skeletal muscle.  This turned out to be an operation of increased complexity as a result of the direct involvement of the Central Nervous System in the motor nerves network and the signal information being eventually analyzed within the centers of ultimate intelligence, i.e. the brain.  Therefore, the signal of a device delivered to the motor nerve had to be excessively refined to pass the Central Nervous Systems gates of resistance before it reached the brain where the orders for hormonal secretion are initiated.  Gerry Pollock built an analogue (unlimited resolution) signal over a period of 30 years research on the basis of motor neuron cells firings during network communications processes.  The latest device with an advanced version of Gerry Pollock’s analogue waveform was utilized by our research group in February 2009.  Nineteen subjects participated in the study.  Results revealed that this analogue signal triggered a series of biological events that clinically resulted in erythrocytes separation, as well as a reduction in fungal forms, pokilocytosis (free radicals) and thrombotic aggregation.  Erythrocyte separation is crucial for the overall blood flow and timely transport of hormones, antibodies, oxygen and nutrients to the cells, and waste products to the kidneys.  Simultaneously, motor nerves’ feedback to the brain enhances the secretion of endogenous Thyroid and Growth hormones that ultimately result in lipolysis and muscle hyperthrophy.  Medical benefits for Heart Disease, Intolerance to Statins and Diabetes are discussed.

INTRODUCTION:
Pacemaker Technology’s dynamic, multi-sine, analogue waveform designed for the motor nerve was originally tested at the cellular level by Dr. Donald Gilbert, a molecular biologist, in the eighties.  The Pacemaker Technology for the skeleral muscle was electronically engineered by the Pacemaker co-inventors (2008), after 30 years of research, to resonate the motor nerve’s signal of strenuous exercise normally emitted by the brain. Due to its resonance with the biological signal, this analogue motor nerve specific signal spreads throughout the CNS inducing effortless and painless isometric and isotonic muscle contractions.  The signal to the nerve ultimately triggers hormonal secretion such as Growth Hormone (GF), Thyroxine (T4) and Triiodothyronine (T3) for lipolysis and Insulin Growth Factor (IGF-1) for muscle hypertrophy.

Muscle stimulation does not automatically release hormones because neuronal synapses activated out of sync with the other inputs to the neuron stand out as odd and are eliminated.  Neuronal synapses that are activated in sync with other inputs to the neuron are strengthened.  The signal of a device must be in sync with the biological choreography in order to spread via the spinal cord and reach the brain.  In sync, or resonance, has been touted by a number of approximate hit-or-miss techniques involving magnetic and electrical fields with dubious inconsistent results.  But no technology has ever reached the accuracy of building a specific signal designed to re-enact circuitous motor neuron firings as those occurring during complex motor activity such as exercise.  There are several reasons why such technology has not demonstrated the advancement seen in other scientific areas.  The most important of these reasons is that such technology illustrates the necessity of understanding biological systems as dynamic system networks that are basically in eternal flux.  An example of a general event underlying the functions of all proteins is the revelation that did not come until 2000 that concentrations pf p53 protein oscillate over time – just as the “true” and “false” states oscillate in a liar paradox.  Only then were the details of this protein’s dynamic behavior truly appreciated.  The second most important reason has to do with the meticulous, painstaking, empirical observation of the dynamic behavior of neuronal events where now you see it, now you don’t, and were each presence or absence of such neuronal events must be understood and decoded before a resonant signal is engineered.  The third reason has to do with the digital revolution and the neglect of the fact that only analogue signals have the unlimited resolution necessary to map the elaborate composition of motor nerve signals.  This is exactly what the Pacemaker technology for the skeleral muscle has accomplished. The Pacemaker co-inventors engineered the advanced device used in our study in the European Union funded Research Center, Innovations Science, UK.  The analogue signal of the device consists of up to 2,000 frequencies that are intertwined to resonate the brain’s signal to the motor nerve that leads to a full force, high-speed workout.  This high speed workout re-enactment occurs without effort, without actual movement, lactic acid formation, side effects or pain.  Due to its bio-similarity, the Pacemaker Technology for the Skeletal Muscle (PTSM) can enhance endogenous hormonal secretion.  Lipolysis and muscle hypertrophy following application of this technology have been reported by a number of single subject design clinical studies.

PTSM neuronal microstimulation mobilizes the skeletal muscles into rhythmical contractions the way the Pacemaker sets the heart rhythm by brief resonant signals.   Intracellulaly, this process involves neuronal signals traveling down the spinal cord, carrying the message to the brain via synapses strengthened by virtue of being activated in sync with the nervous sytem communication network. This bio-resonant signal initially targets the motor neurons resulting in rhythmical muscle contractions equivalent to performing high resistance physical activity.  The process is initiated at the peripheral motor neuron, then the circuit is completed by outgoing CNS neuron emission.  This CNS emission can cause the ultimate production of Free T3 and GH/IGF-1, which in turn cause lipolysis and muscular hypertrophy.  Triggering hormonal secretion, however,  is only part of the process.  GF is transported via the blood to the liver to be transformed into IGF-1 which causes muscle hypertrophy. T3 and T4 are also released into the blood stream, being transported throughout the body where they control lipolysis and overall metabolism.  Enhanced RBCs separation facilitates better hormonal transport as well as the transport of oxygen, nutrients, antibodies and waste products to the kidneys.  Therefore it is a key mechanism to hormonal transport as well as other crucial biological functions.

STUDY DESIGN: This blind study was conducted by trained technicians uninformed of the experimental variables.  Nineteen randomly selected subjects (17 females and 2 males) received six 45 minute PTSM treatments every other day.  All subjects completed a medical questionnaire.  None of the subjects reported any medical disorders or being on any special supplements or medications. No special supplements or medications were offered during the study. None of the subjects was on a special diet or regular exercise regime.  The subjects were instructed to drink an average of 6 glasses of water daily.  All subjects were given a 16.9 fluid oz bottle of water prior to the treatment.

METHOD: A drop of the subject’s blood was drawn from the fingertip of each subject and placed on a microscope slide. A special lens inside the microscope projected an
intimate view of the living blood onto a computer screen by way of a video camera. The camera was hooked up to the microscope enabling the taking of photographs of each subject’s blood sample before and after treatment. There were at least 5 pictures taken from different aspects of each sample to control for the possibility of contaminating the validity and reliability of the results by selecting a certain aspect of the sample over another.

VARIABLES:
1.  Erythroctyte Separation:  The presence of round, separated, freely moving erythrocytes.
2.  Rouleau:  A condition in which the red blood cells are clumped together and stacked like coins.  This suggests the presence of free radicals.  Rouleau affects proper oxygenation and favors the growth of unhealthy organisms that can survive in a milieu that is less oxygen rich. Fungi, bacteria, and viruses require less oxygen than healthy tissue.
3.  Erythrocyte Aggregation:  A condition one step worse than rouleau. This is often seen in people with degenerative diseases, degeneration of tissue, low oxygen and acidity. This condition can precede a blood clot which can cause a stroke or heart attack.
4.  Poikilocytosis:  A condition caused by free radicals. Usually, free radical damage signifies that there will also be damage to the nuclei of tissue cells.
5.  Fungal Forms:  A sign of poor assimilation of nutrients and an acidic condition in the body fluids
6. Bacteria
7.  Thrombocyte Aggregation:  Thrombocytes (platelets) aggregate even though there is no injury.

RESULTS: The results of the study are given on the table below (figure 1) that indicates the number of subjects under the variables.

(figure 1)

1.  After the first treatment  nine subjects presented rouleau plus some freely
flowing RBCs and three subjects showed complete RBCs separation.
2. Prior to the last treatment 11 subjects revealed mostly separate RBCs as well as rouleau.
3. After the last treatment, sixteen of the subjects had mostly round, separated, freely moving erythrocytes.  Two of the subjects had mostly RBCs separation and some rouleau and one subject had mostly rouleau and minimal RBCs separation.
4. Six out of eight subjects with Fungal Forms and Thrombocyte Aggregation prior to treatment, showed no Fungal Forms and no Thrombocyte Aggregation after the last treatment.
5. Six out of nine subjects with Bacteria prior to the first treatment
presented no Bacteria after the last treatment.
6. 100% of subjects with Pokilocytosis, showed no evidence of Pokilocytosis after the last treatment

CONCLUSION: The results of this clinical microscopy study are summarized as follows and shown in figure 2:
1.  Pacemaker Technologye (PTSM)  treatments result  in an  overall  improvement in terms of normalized RBCs separation.
2. On the average, RBCs separation appears to linearly improve with increased number of  treatments.
3.  Pacemaker Technologye  treatments appear to have a negative correlation with the number of  fungal forms, poikilocytosis, thrombocyte aggregation and bacteria present in the blood prior to the PTSM treatments, demonstrating a significant reduction of all of the above mentioned variables.
4.  The enhanced erythrocyte separation as well as the reduction of fungal forms, poikilocytosis, thrombocyte aggregation and bacteria persisted during the intervals between treatments.  A longitudinal study is necessary to investigate the total length of time during which such normalization effects continue to be present.  So far, two subjects that have been followed up over a period of three months have sustained the Pacemaker Technologye’s positive effects on RBCs separation.

(figure 2)

This technology that was initially based on research associated with the Pacemaker and gained its popularity in the field of body building and cosmetic procedures  is now coming full circle by offering benefits that can be potentially used in Medicine to reduce the incidence or progression of cardiac disorders resulting from erythrocyte aggregation.   PTSM treatments effortlessly exercise the body without lactic acid production while enhancing RBCs separation.  This process of exercising without actually exercising could solve the dilemma caused by intolerance to Statins which is associated with intolerance to exercise.

INTOLERANCE TO STATINS:
It is well recognized that Statins, medically used to down regulate the blood coagulation cascade, affect muscular tissue adversely.  Treatment with Statins is associated with clinically important myositis, rhabdomyolysis, mild elevation of serum creatine kinase (CK) levels, myalgias, muscle weakness, and muscle cramps. In Statin patients muscular problems occur more frequently during and after exercise (Franc et al, 2003 ; Searchrist et al, 2005). Sinzinger and O’Grady (2004) found that 78% of professional athletes with familial hypercholesterolemia could not tolerate therapy with any Statin due to muscle pain and cramps.  There is a growing evidence that Statins promote apoptosis in different cell types including vascular smooth muscle cells, and endothelial cells (Kaneta et al., 2003; Shellman et al, 2005; Wibaut-Berlaimont et al, 2005).  Pacemaker Technologye (PTSM) treatments result in RBCs separation.  Such normalization of blood flow can possibly reduce the risk of heart disease reducing the need for Statins.  Additionally, Pacemaker Technology effortlessly exercises  the muscles without lactic acid formation, thus reducing intolerance to Statins.

MITOCHONDRIA AND AGING:
Abnormal mitochondrial function and  compromised energy production are an increasingly recognized cause of neuromuscular disease and aging. Evidence of impaired rephosphorylation of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) during recovery from exercise was found in almost half the patients (Arnold 1984).    ADP is transformed into ATP via the proton motive force (driven by the electron transport chain) that spins the ATPase module clockwise. Without the proton motive forcer the ATPase module spins anti-clockwise breaking energy down (dephosphorylation of ATP into ADP and a Phoshate.)  The miniscule ultra low microcurrent of the Ion Mangum offers the system an influx of electrons which in conjunction of the enhanced oxygen transport, the result of erythrocyte separation, can facilitate and increase ATP production.  Note that the ATPase module is a key time reversal mechanism, spinning clockwise to produce energy and anti-clockwise, or backwards to break it down.    This can perhaps explain the significant anti-aging effects consistently observed after Pacemaker Technologye treatments.

CALCIUM HOMEOSTASIS & AGING:
Chua et al, (2005) evaluated eleven patients with increased creatine kinase (CK) levels and myalgias after Statin treatment, using in vitro contracture tests (IVCTs), histology, and 31P magnetic resonance spectroscopy (31P-MRS).  IVCT results were abnormal in 7 out of 9 patients, indicating an impaired calcium homeostasis. Calcium homeostasis refers to the regulation of the concentration of calcium ions in the extracellular fluid [Ca++]ECF. This parameter is tightly controlled because the calcium ions have a stabilizing effect on voltage-gated ion channels which are responsible for generation of electrical signals in cell membranes. For instance, when [Ca++]ECF is too low (hypocalcemia), voltage-gated ion channels start opening spontaneously, causing nerve and muscle cells to become hyperactive. Conversely, when [Ca++]ECF is too high (hypercalcemia), voltage-gated ion channels don’t open as easily, and there is depressed nervous system function. Another problem of hypercalcemia is that calcium can combine with phosphate ions, forming deposits of calcium phosphate (stones) in blood vessels and the kidneys. Evidence suggests that disturbance of calcium homeostasis is important in neurodegeneration and aging (Lally et al, 2005). Peterson et al, (2006)  reported that Alzheimer’s donors have higher levels of bound calcium but lower concentrations of free intracellular calcium when compared to cells from young and normal aged donors.  Squil et. al’s research (2008) in the National Institute of Anti-aging focuses on the molecular mechanisms that result in the age-dependent loss of calcium regulation in neurons, which correlates with an increased sensitivity to stress and age-related declines in cognitive function. They are presently working in trying to identify a linkage between oxidative stress and decreased calcium regulation observed during aging.    The intimate connection between ion channels, the  electrical heart of the cell, and calcium homeostasis places Pacemaker Technologye’s key to lock bio-resonant waveform  center  stage.   A signal in sync with the nervous system  may be absorbed by the system to regulate and stabilize ion channels and hence  normalize overall nervous system functioning, offering an ion based time reversal mechanism.

OXIDATIVE STRESS AND AGING:
Oxidative stress has been postulated as one of the primary causes of aging from a number of investigators (Landis et al, 2004).  Sinclair et al, (2007) in Harvard University has identified identical biological substrates in oxidative stress and aging.  Oxidative stress can be effectively combatted by an electron influx donating the missing electrons to free radicals.  Free radicals that receive their missing electron are transformed back into their original form of stable molecules — a basic yet, very powerful time reversal mechanism.
The consensus on the electrical properties of DNA is that DNA utilizes electrons to deflect oxidative damage from itself, safeguarding against aging, disease and impaired protein formation.  Impaired protein formation leads to diminished cellular intelligence, as proteins are the brain of the cell. Electrons, the key element against oxidative damage, are the very essence of Pacemaker Technologye’s ultra microcurrent signal.

IONIC FACTOR SEEN AS A BIOLOGICAL HUB:  Several of the common denominators of intolerance to Statins and aging appear to be related to insufficient biological ionic biological activity represented by: a) impaired calcium homeostasis affecting ion channels, b) mitochondrial impairment leading to energy shortage, and c) oxidative stress, as a result of free radicals which are stable molecules missing one of their electrons.  PTSM bio-resonant signal  can spread into the CNS to enhance ATP production in the mitochondria.  It can donate electrons to the electron seeking free radicals hence turning them into stable molecules to reduce oxidative damage.  Reduced oxidative damage will allow for healthier DNA and proteins. PTSM key to lock bio-resonant waveform may be absorbed by the system and utilized in ion channels regulation which may play a central role in reversing neuro-degeneration and aging.  From this point of view ionic activity can be seen as a biological hub interconnecting a number of biological activities that are crucial in anti-aging as well as the maintenance of an optimal health status

DIABETES MELLITUS II
Individual phenotypic differences result in a variation of T4 to Free T3 conversion. Free T3 stimulates lipolysis. This leads to polymorphic and individualized lipid deposition patterns. Hyperthyroidism is associated with weight loss via an increase in metabolic rate and lipolysis. A  literature review  by Guillermo et al, (2003) has shown that the risk of thyroid dysfunction in Diabetic patients is two to threefold higher than in the general population. Although the benefits of intensified insulin treatment in insulin dependent Diabetes Mellitus are well recognized, a meta-analysis of 14 randomized controlled trials revealed the risk of severe Hypoglycemia, Ketoacidosis and mortality from acute metabolic causes with intensified insulin treatment. These 14 trails contributed 16 comparisons with 1028 patients allocated to intensified and 1039 allocated to conventional treatment. A total of 846 patients suffered at least one episode of severe hypoglycaemia, 175 patients experienced ketoacidosis and 26 patients died. We are investigating an alternative treatment for Diabetes with no side effects. This involves the enhancement of endogenous production of Free T3 and IGF-1 via the Pacemaker Technologye signal.
1. PTSM Initially targets the motor neurons resulting in rhythmical muscle contractions equivalent to performing high resistance physical activity. 2. Once the process is initiated, the motor neurons signal the brain  via  the spinal  cord. This  is  a  physiologically reversed process, where the strenuous exercise signal does not originate in the brain traveling down the spinal cord. Instead, the process is initiated at the peripheral motor neuron, then the circuit is completed by outgoing CNS neuron emission. 3. This CNS emission causes the ultimate production of Free T3 and GH/IGF-1, which in turn cause lipolysis and muscular hypertrophy. The enhanced production of Free T3 and GF/IGF-I will temporarily cause hyperglycemia which will resolve once the glucose has been utilized for metabolic purposes, energy increase
and muscular hypertrophy.

SUMMARY: Pacemaker Technology treatments appear beneficial in A. Muscle Building; B. Lipolysis; C. Anti-Aging; D. Erythrocyte Separation; E. Possibly Reducing the risk of Heart Disease; F. Reducing Oxidative Damage; F. Possibly Reducing the need for Statins; G. Possibly Reducing intolerance to Statins; H. Increasing ATP; I. Possibly Re-establishing Calcium Homeostasis.  J. Enhancing Secretion and Transport of Thyroid and Growth Hormones.

IONIC TECHNOLOGY AND DYNAMIC AGE REVERSAL:
According to the microscopic laws of physics, for every allowed process there exists a time-reversed process, a principle that applies to molecular biological events.  For example, Shanklin et al (2006) found that a single substitution in the amino acid sequence of an enzyme seemed to turn the clock 2.5 billion years back.
Endogenous ionic activity appears to be crucial in a number of key bio-molecular processes as well as life sustaining and reparative mechanisms:
1. Amino acids form proteins, being attracted to each other by virtue of their electrical charges.
2. Electrons turn the clock back by transforming free radicals into the stable molecules they were prior to oxidative damage.
3. Driven by the Proton Motive Force, ATPase rotates clockwise to produce ATP or anti-clockwise to break ATP down to ADP and a Phosphate.
4. DNA uses electrons to deflect oxidative damage away from its important sections.
5. The body is empowered by endogenous electrical fields to heal itself.
6. Ion Channels are involved in cell division and differentiation, initiation of immune responses and bio-electrochemical communication.
In conclusion, several life sustaining and time reversal processes appear to be electrical.

The single minded focus of this research group is to continue fine tuning ‘device — body’ communications on the basis of knowledge accumulated by the Pacemaker technology specializing in the unique interaction between electronic keys fitting biological lock mechanisms.

References:
Peterson C, Ratan R, Shelanski M, Goldman J. Changes in Calcium Homeostasis during Aging and Alzheimer’s Disease.  Annals of the New York Academy of Sciences. 2009; 568: 262 - 270
Lally G, Faull RLM, Waldvogel HJ, Ferrar S, Emson PC. Calcium homeostasis in ageing: studies on the calcium binding protein calbindin D28K. J of Neural Transmission. 1997; 104: 1107-1112
Catterall W. Structure and Function of Voltage-Gated Ion Channels. Annu. Rev. Biochem. 1995. 64: 493-531
Zhang JD, Han J.  A modular network model of aging.  Molecular Systems Biology. 2007: 3:147
Zhao M, Song B, Pu1 J, Wada T, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-g and PTEN. Nature 2006; 44: 2|27-2138
Uchikoga N, Takahashi SY, Ke R, et al. Design and self-assembly of two dimensional DNA crystal. Nature. 1998 394-539
Pidder JD,  Heinz DO. Healthy ageing: a question of stress, damage and repair. Meeting on mechanisms of biological ageing.  EMBO Reports. 2002;  3: 12: 1127–1132

Xanya Sofra-Weiss, Ph.D

Abstract:

The aging process cannot be conceptualized by examining a single gene or a single pathway, but can best be addressed at the systems level. Aging is not only the sum total of shortened telomeres, denatured proteins and DNA molecules, or oxidative damage in the mitochondria. Aging attacks key regulatory nodes crucial for the biological network stability. It is the dynamic process of increasing imbalances in the systemic organization of degenerating biological processes. DNA and stem cells engineering have successfully reversed certain individual components of time attrition resulting in rejuvenation and aging delay. So far, research has merely followed a sequential process that goes from the part to the whole, identifying aging genes and engineering stem cells, etc. However, discovering pieces of the puzzle still requires identification of the interconnections between matching pieces before the solution emerges. The old, the ill, and the injured all suffer from misarranged patterns of atoms. A single substitution an A for a G in a DNA molecule can cause a significant change in the conductance of the molecule leading to cancer. Such research findings demonstrate how the sequence and interrelations of amino acids in a protein, or the sequence of base pairs in a DNA molecule can become determining factors between health and disease, aging and youth. The DNA sequence alone doesn’t determine everything. The importance of the spatial organization or nuclear architecture in regulating gene expression begs for scientific observation that does not merely focus on the study of atoms and molecules, (the basic components of a Gestalt); but on the interrelations, sequence, orientation and spatial organization of these atoms and molecules (the dynamic whole or Gestalt). Recent research has shown that DNA, proteins, cells, including stem cells, appear to be electrical in that they demonstrate conductivity or the presence of ionic currents. Since electricity is a dynamic entity emerging out of the interactions of atoms and molecules, we propose that perhaps the simplest way of focusing on the entire system is by decoding the complex electrical signals that map biological interactions with respect to spatial organization. Biological signals must be analyzed in terms of their amperage, frequency, voltage, interactions, orientation, spatial organization. Next will be their translation into electronic signals that comply with the specifications of amperage, frequency, voltage or biological signals. Electronic signals will then be intertwined to orchestrate a Gestalt waveform built on the basis of information attained from observations of biological interactions and architecture – a process similar to that done in Pollock’s lab (1990-2004). This Gestalt waveform will act as an electronic diplomat to awaken biological processes that have diminished with aging or disease by signaling the recuperation and activation of biological reparative mechanisms leading to extended longevity.

A clinical study with individuals presenting abnormally clumped Red Blood Cells’ (RBCs) was completed in February 2009 with a device representing the Pacemaker Technology for the Skeletal muscle. Results indicate that this technology rapidly and efficiently leads to normalized erythrocytes’ separation at the microscopic level. RBCs separation is crucial for the overall blood flow and timely transport of hormones, antibodies, oxygen and nutrients to the cells, and waste products to the kidneys. Transport of Hormones is a crucial process lipolysis (T3 and Growth Hormone — GF) and muscle hypertrophy (Insulin Growth Factor - IGF-1). Additionally, erythro cyte separation resulting from treatment with the Pacemaker Technology appears to have a negative correlation with the number of fungal forms, poikilocytosis, thrombocyte aggregation and bac teria present in the blood prior to treatments. In summary, the erythrocyte separation resulting from treatments with the Pacemaker Thechology enhances hormonal transport including T3 and GH leading to lipolysis and muscle hypertrophy; 2) RBC;s separation enhances overall level of health by a significant reduction of free radicals. bacteria, fungal forms. etc.; 3) Obesity is characterized by reduced blood flow. The Pacemaker Thechology increases RBC’s separation resulting in normalized blood flow. In conclusion, re-establishing normal levels of blood flow will not only help reduce obesity but it will help reduce the risk of heart attack as well as all other disorders associated with obesity. Due to its resonance with the biological signal and following the rule of reinforced synapses when signals are in synch with the CNS, the signal of the Pacemaker Technology spreads throughout the CNS inducing effortless and painless isometric and isotonic muscle contractions. The Pacemaker Technology signal to the nerve ultimately triggers hormonal secretion such as Growth Hormone (GF), Thyroxine (T4) and Triiodothyronine (T3) for lipolysis and Insulin Growth Factor (IGF-1) for muscle hypertrophy.

Goals and Objectives
(1)To integrate the diverse data on aging genes, cellular oxidative damage, telomere attrition, protein and DNA denaturation and mitochondria damage into a unified theory that addresses aging at the systems level.
(2)To discuss studies that have used ionic currents to enhance molecular reparative mechanisms.
(3)To introduce clinical and experimental results obtained with the Pacemaker Technology
(4)To introduce the ionic currents model of anti-aging for rejuvenation and obesity and discuss consequential medical benefits involved with this technology.

Xanya Sofra-Weiss

Aging is not just the sum total of individually deteriorating cells. Aging is the dynamic process of increasing imbalances in the systemic organization of these cells. Anti-aging reflects a multilevel appoach that simultaneously targets a number of biological network modules. Indentifying these dynamically organized network modules will be very important in formulating a model of how and why the aging process takes place and whether or not we can reverse aging by reorganizing an aged network model. The old, the ill, and the injured all suffer from misarranged patterns of atoms, whether misarranged by aging and accumulated free radicals, invading viruses, or unfortunate accidents. Aged and young are the Gestalts on opposite poles composed of variations in the arrangement of their dynamically organized networks. Modern electronics and molecular biology research are combined to deduce the specifications for a technology that promotes Healthy Anti-aging. Resonating the firings, spatial organization and rhythms of electrically excitable cells leads to healing and rejuvenation in a completely safe, noninvasive method.

Xanya Sofra-Weiss, Ph.D

Individual phenotypic differences result in a variation of T4 to Free T3 conversion. Free T3 stimulates lipolysis. This leads to polymorphic and individualized lipid deposition patterns. Hyperthyroidism is associated with weight loss via an increase in metabolic rate and lipolysis. Hypothyroidism, on the other hand, is associated with weight gain via a decrease in metabolic rate. A literature review by Guillermo et al (2003) has shown that the risk of thyroid dysfunction in Diabetic patients is two- to threefold higher than in the general population. A number of studies have shown that thyroid hormones represented by serum total T3 and T4 concentrations and serum Free T3 and T4 concentrations were significantly lower in obese non-insulin-dependent diabetics than control subjects. Low T3 is also a strong predictor of mortality in cardiac patients and may be directly implicated in the poor prognosis of cardiac patients. Although the benefits of intensified insulin treatment in insulin-dependent Diabetes Mellitus are well recognized, a meta-analysis of 14 randomized controlled trials revealed the risk of severe Hypoglycemia, Ketoacidosis and mortality from acute metabolic causes with intensified insulin treatment. These 14 trails contributed 16 comparisons with 1028 patients allocated to intensified and 1039 allocated to conventional treatment. A total of 846 patients suffered at least one episode of severe hypoglycaemia, 175 patients experienced ketoacidosis and 26 patients died. We are investigating an alternative treatment for Diabetes with no side effects. This involves the enhancement of endogenous production of Free T3 and IGF-1 via an electronically designed ionic signal. The mechanism of this therapeutic signal delivery was invented by Pollock, (1990-2008), in Innovations Science, a European Community-funded research center. Using the Pacemaker technology this ionic signal produces the physiological responses associated with strenuous exercise. Pollock’s ionic signal (image 1) initially targets the motor neurons resulting in rhythmical muscle contractions equivalent to performing high resistance physical activity. Once the process is initiated by Pollock’s bio-identical electronic signal, the motor neurons signal the brain via the spinal cord. This is a physiologically Beyond Bio-identical Hormones Ongoing Research on A New Potential Treatment for Adult reversed process, like traffic being driven the opposite way, where the strenuous exercise signal does not originate in the brain traveling down the spinal cord to the motor nerve. Instead, the process is initiated at the peripheral motor neuron, then the circuit is completed by outgoing CNS neuron emission. This CNS emission causes the ultimate production of Free T3 and GH/IGF-1, which in turn cause lipolysis and muscular hypertrophy. The enhanced production of Free T3 and GF/IGF-I will temporarily cause hyperglycemia. However, the hyperglycemia will resolve once the glucose has been utilized for metabolic purposes including increased cellular energy and muscular hypertrophy. The aim of this study is to test the hypothesis that the use of ionic currents may reduce or eliminate adult onset Diabetes.