Blog Arasys Perfector - Xanya Sofra Weiss

Rapid and Efficient Erythrocyte Separation by
Ionic Pacemaker Technology for the Skeletal Muscle

Xanya Sofra-Weiss, Ph.D

ABSTRACT

The complexity of aging mechanisms demands a research platform with a systems-level view capable of meeting the multidimensional manifestation of self-disorganizing, self- repairing life processes.  Our research is based on neuro-resonance signaling technology that acts as an ambassador to the vast intelligence network of the nervous system.  A neuro-resonant “ambassador” is necessary considering the abundance of unknown immune functions and resistances within the body that will a) eliminate any signals or agents inconsistent with the overall neurocommunications; b) lead to a negative feedback loop mechanism that will inhibit self repairing processes. This technology was originally developed for the smooth heart muscle by the inventors of the pacemaker.  One of the pacemaker co-inventors, Gerry Pollock extended the knowledge accumulated from the smooth muscle to the motor nerves of the skeletal muscle.  This turned out to be an operation of increased complexity as a result of the direct involvement of the Central Nervous System in the motor nerves network and the signal information being eventually analyzed within the centers of ultimate intelligence, i.e. the brain.  Therefore, the signal of a device delivered to the motor nerve had to be excessively refined to pass the Central Nervous Systems gates of resistance before it reached the brain where the orders for hormonal secretion are initiated.  Gerry Pollock built an analogue (unlimited resolution) signal over a period of 30 years research on the basis of motor neuron cells firings during network communications processes.  The latest device with an advanced version of Gerry Pollock’s analogue waveform was utilized by our research group in February 2009.  Nineteen subjects participated in the study.  Results revealed that this analogue signal triggered a series of biological events that clinically resulted in erythrocytes separation, as well as a reduction in fungal forms, pokilocytosis (free radicals) and thrombotic aggregation.  Erythrocyte separation is crucial for the overall blood flow and timely transport of hormones, antibodies, oxygen and nutrients to the cells, and waste products to the kidneys.  Simultaneously, motor nerves’ feedback to the brain enhances the secretion of endogenous Thyroid and Growth hormones that ultimately result in lipolysis and muscle hyperthrophy.  Medical benefits for Heart Disease, Intolerance to Statins and Diabetes are discussed.

INTRODUCTION:
Pacemaker Technology’s dynamic, multi-sine, analogue waveform designed for the motor nerve was originally tested at the cellular level by Dr. Donald Gilbert, a molecular biologist, in the eighties.  The Pacemaker Technology for the skeleral muscle was electronically engineered by the Pacemaker co-inventors (2008), after 30 years of research, to resonate the motor nerve’s signal of strenuous exercise normally emitted by the brain. Due to its resonance with the biological signal, this analogue motor nerve specific signal spreads throughout the CNS inducing effortless and painless isometric and isotonic muscle contractions.  The signal to the nerve ultimately triggers hormonal secretion such as Growth Hormone (GF), Thyroxine (T4) and Triiodothyronine (T3) for lipolysis and Insulin Growth Factor (IGF-1) for muscle hypertrophy.

Muscle stimulation does not automatically release hormones because neuronal synapses activated out of sync with the other inputs to the neuron stand out as odd and are eliminated.  Neuronal synapses that are activated in sync with other inputs to the neuron are strengthened.  The signal of a device must be in sync with the biological choreography in order to spread via the spinal cord and reach the brain.  In sync, or resonance, has been touted by a number of approximate hit-or-miss techniques involving magnetic and electrical fields with dubious inconsistent results.  But no technology has ever reached the accuracy of building a specific signal designed to re-enact circuitous motor neuron firings as those occurring during complex motor activity such as exercise.  There are several reasons why such technology has not demonstrated the advancement seen in other scientific areas.  The most important of these reasons is that such technology illustrates the necessity of understanding biological systems as dynamic system networks that are basically in eternal flux.  An example of a general event underlying the functions of all proteins is the revelation that did not come until 2000 that concentrations pf p53 protein oscillate over time – just as the “true” and “false” states oscillate in a liar paradox.  Only then were the details of this protein’s dynamic behavior truly appreciated.  The second most important reason has to do with the meticulous, painstaking, empirical observation of the dynamic behavior of neuronal events where now you see it, now you don’t, and were each presence or absence of such neuronal events must be understood and decoded before a resonant signal is engineered.  The third reason has to do with the digital revolution and the neglect of the fact that only analogue signals have the unlimited resolution necessary to map the elaborate composition of motor nerve signals.  This is exactly what the Pacemaker technology for the skeleral muscle has accomplished. The Pacemaker co-inventors engineered the advanced device used in our study in the European Union funded Research Center, Innovations Science, UK.  The analogue signal of the device consists of up to 2,000 frequencies that are intertwined to resonate the brain’s signal to the motor nerve that leads to a full force, high-speed workout.  This high speed workout re-enactment occurs without effort, without actual movement, lactic acid formation, side effects or pain.  Due to its bio-similarity, the Pacemaker Technology for the Skeletal Muscle (PTSM) can enhance endogenous hormonal secretion.  Lipolysis and muscle hypertrophy following application of this technology have been reported by a number of single subject design clinical studies.

PTSM neuronal microstimulation mobilizes the skeletal muscles into rhythmical contractions the way the Pacemaker sets the heart rhythm by brief resonant signals.   Intracellulaly, this process involves neuronal signals traveling down the spinal cord, carrying the message to the brain via synapses strengthened by virtue of being activated in sync with the nervous sytem communication network. This bio-resonant signal initially targets the motor neurons resulting in rhythmical muscle contractions equivalent to performing high resistance physical activity.  The process is initiated at the peripheral motor neuron, then the circuit is completed by outgoing CNS neuron emission.  This CNS emission can cause the ultimate production of Free T3 and GH/IGF-1, which in turn cause lipolysis and muscular hypertrophy.  Triggering hormonal secretion, however,  is only part of the process.  GF is transported via the blood to the liver to be transformed into IGF-1 which causes muscle hypertrophy. T3 and T4 are also released into the blood stream, being transported throughout the body where they control lipolysis and overall metabolism.  Enhanced RBCs separation facilitates better hormonal transport as well as the transport of oxygen, nutrients, antibodies and waste products to the kidneys.  Therefore it is a key mechanism to hormonal transport as well as other crucial biological functions.

STUDY DESIGN: This blind study was conducted by trained technicians uninformed of the experimental variables.  Nineteen randomly selected subjects (17 females and 2 males) received six 45 minute PTSM treatments every other day.  All subjects completed a medical questionnaire.  None of the subjects reported any medical disorders or being on any special supplements or medications. No special supplements or medications were offered during the study. None of the subjects was on a special diet or regular exercise regime.  The subjects were instructed to drink an average of 6 glasses of water daily.  All subjects were given a 16.9 fluid oz bottle of water prior to the treatment.

METHOD: A drop of the subject’s blood was drawn from the fingertip of each subject and placed on a microscope slide. A special lens inside the microscope projected an
intimate view of the living blood onto a computer screen by way of a video camera. The camera was hooked up to the microscope enabling the taking of photographs of each subject’s blood sample before and after treatment. There were at least 5 pictures taken from different aspects of each sample to control for the possibility of contaminating the validity and reliability of the results by selecting a certain aspect of the sample over another.

VARIABLES:
1.  Erythroctyte Separation:  The presence of round, separated, freely moving erythrocytes.
2.  Rouleau:  A condition in which the red blood cells are clumped together and stacked like coins.  This suggests the presence of free radicals.  Rouleau affects proper oxygenation and favors the growth of unhealthy organisms that can survive in a milieu that is less oxygen rich. Fungi, bacteria, and viruses require less oxygen than healthy tissue.
3.  Erythrocyte Aggregation:  A condition one step worse than rouleau. This is often seen in people with degenerative diseases, degeneration of tissue, low oxygen and acidity. This condition can precede a blood clot which can cause a stroke or heart attack.
4.  Poikilocytosis:  A condition caused by free radicals. Usually, free radical damage signifies that there will also be damage to the nuclei of tissue cells.
5.  Fungal Forms:  A sign of poor assimilation of nutrients and an acidic condition in the body fluids
6. Bacteria
7.  Thrombocyte Aggregation:  Thrombocytes (platelets) aggregate even though there is no injury.

RESULTS: The results of the study are given on the table below (figure 1) that indicates the number of subjects under the variables.

(figure 1)

1.  After the first treatment  nine subjects presented rouleau plus some freely
flowing RBCs and three subjects showed complete RBCs separation.
2. Prior to the last treatment 11 subjects revealed mostly separate RBCs as well as rouleau.
3. After the last treatment, sixteen of the subjects had mostly round, separated, freely moving erythrocytes.  Two of the subjects had mostly RBCs separation and some rouleau and one subject had mostly rouleau and minimal RBCs separation.
4. Six out of eight subjects with Fungal Forms and Thrombocyte Aggregation prior to treatment, showed no Fungal Forms and no Thrombocyte Aggregation after the last treatment.
5. Six out of nine subjects with Bacteria prior to the first treatment
presented no Bacteria after the last treatment.
6. 100% of subjects with Pokilocytosis, showed no evidence of Pokilocytosis after the last treatment

CONCLUSION: The results of this clinical microscopy study are summarized as follows and shown in figure 2:
1.  Pacemaker Technologye (PTSM)  treatments result  in an  overall  improvement in terms of normalized RBCs separation.
2. On the average, RBCs separation appears to linearly improve with increased number of  treatments.
3.  Pacemaker Technologye  treatments appear to have a negative correlation with the number of  fungal forms, poikilocytosis, thrombocyte aggregation and bacteria present in the blood prior to the PTSM treatments, demonstrating a significant reduction of all of the above mentioned variables.
4.  The enhanced erythrocyte separation as well as the reduction of fungal forms, poikilocytosis, thrombocyte aggregation and bacteria persisted during the intervals between treatments.  A longitudinal study is necessary to investigate the total length of time during which such normalization effects continue to be present.  So far, two subjects that have been followed up over a period of three months have sustained the Pacemaker Technologye’s positive effects on RBCs separation.

(figure 2)

This technology that was initially based on research associated with the Pacemaker and gained its popularity in the field of body building and cosmetic procedures  is now coming full circle by offering benefits that can be potentially used in Medicine to reduce the incidence or progression of cardiac disorders resulting from erythrocyte aggregation.   PTSM treatments effortlessly exercise the body without lactic acid production while enhancing RBCs separation.  This process of exercising without actually exercising could solve the dilemma caused by intolerance to Statins which is associated with intolerance to exercise.

INTOLERANCE TO STATINS:
It is well recognized that Statins, medically used to down regulate the blood coagulation cascade, affect muscular tissue adversely.  Treatment with Statins is associated with clinically important myositis, rhabdomyolysis, mild elevation of serum creatine kinase (CK) levels, myalgias, muscle weakness, and muscle cramps. In Statin patients muscular problems occur more frequently during and after exercise (Franc et al, 2003 ; Searchrist et al, 2005). Sinzinger and O’Grady (2004) found that 78% of professional athletes with familial hypercholesterolemia could not tolerate therapy with any Statin due to muscle pain and cramps.  There is a growing evidence that Statins promote apoptosis in different cell types including vascular smooth muscle cells, and endothelial cells (Kaneta et al., 2003; Shellman et al, 2005; Wibaut-Berlaimont et al, 2005).  Pacemaker Technologye (PTSM) treatments result in RBCs separation.  Such normalization of blood flow can possibly reduce the risk of heart disease reducing the need for Statins.  Additionally, Pacemaker Technology effortlessly exercises  the muscles without lactic acid formation, thus reducing intolerance to Statins.

MITOCHONDRIA AND AGING:
Abnormal mitochondrial function and  compromised energy production are an increasingly recognized cause of neuromuscular disease and aging. Evidence of impaired rephosphorylation of adenosine diphosphate (ADP) to adenosine triphosphate (ATP) during recovery from exercise was found in almost half the patients (Arnold 1984).    ADP is transformed into ATP via the proton motive force (driven by the electron transport chain) that spins the ATPase module clockwise. Without the proton motive forcer the ATPase module spins anti-clockwise breaking energy down (dephosphorylation of ATP into ADP and a Phoshate.)  The miniscule ultra low microcurrent of the Ion Mangum offers the system an influx of electrons which in conjunction of the enhanced oxygen transport, the result of erythrocyte separation, can facilitate and increase ATP production.  Note that the ATPase module is a key time reversal mechanism, spinning clockwise to produce energy and anti-clockwise, or backwards to break it down.    This can perhaps explain the significant anti-aging effects consistently observed after Pacemaker Technologye treatments.

CALCIUM HOMEOSTASIS & AGING:
Chua et al, (2005) evaluated eleven patients with increased creatine kinase (CK) levels and myalgias after Statin treatment, using in vitro contracture tests (IVCTs), histology, and 31P magnetic resonance spectroscopy (31P-MRS).  IVCT results were abnormal in 7 out of 9 patients, indicating an impaired calcium homeostasis. Calcium homeostasis refers to the regulation of the concentration of calcium ions in the extracellular fluid [Ca++]ECF. This parameter is tightly controlled because the calcium ions have a stabilizing effect on voltage-gated ion channels which are responsible for generation of electrical signals in cell membranes. For instance, when [Ca++]ECF is too low (hypocalcemia), voltage-gated ion channels start opening spontaneously, causing nerve and muscle cells to become hyperactive. Conversely, when [Ca++]ECF is too high (hypercalcemia), voltage-gated ion channels don’t open as easily, and there is depressed nervous system function. Another problem of hypercalcemia is that calcium can combine with phosphate ions, forming deposits of calcium phosphate (stones) in blood vessels and the kidneys. Evidence suggests that disturbance of calcium homeostasis is important in neurodegeneration and aging (Lally et al, 2005). Peterson et al, (2006)  reported that Alzheimer’s donors have higher levels of bound calcium but lower concentrations of free intracellular calcium when compared to cells from young and normal aged donors.  Squil et. al’s research (2008) in the National Institute of Anti-aging focuses on the molecular mechanisms that result in the age-dependent loss of calcium regulation in neurons, which correlates with an increased sensitivity to stress and age-related declines in cognitive function. They are presently working in trying to identify a linkage between oxidative stress and decreased calcium regulation observed during aging.    The intimate connection between ion channels, the  electrical heart of the cell, and calcium homeostasis places Pacemaker Technologye’s key to lock bio-resonant waveform  center  stage.   A signal in sync with the nervous system  may be absorbed by the system to regulate and stabilize ion channels and hence  normalize overall nervous system functioning, offering an ion based time reversal mechanism.

OXIDATIVE STRESS AND AGING:
Oxidative stress has been postulated as one of the primary causes of aging from a number of investigators (Landis et al, 2004).  Sinclair et al, (2007) in Harvard University has identified identical biological substrates in oxidative stress and aging.  Oxidative stress can be effectively combatted by an electron influx donating the missing electrons to free radicals.  Free radicals that receive their missing electron are transformed back into their original form of stable molecules — a basic yet, very powerful time reversal mechanism.
The consensus on the electrical properties of DNA is that DNA utilizes electrons to deflect oxidative damage from itself, safeguarding against aging, disease and impaired protein formation.  Impaired protein formation leads to diminished cellular intelligence, as proteins are the brain of the cell. Electrons, the key element against oxidative damage, are the very essence of Pacemaker Technologye’s ultra microcurrent signal.

IONIC FACTOR SEEN AS A BIOLOGICAL HUB:  Several of the common denominators of intolerance to Statins and aging appear to be related to insufficient biological ionic biological activity represented by: a) impaired calcium homeostasis affecting ion channels, b) mitochondrial impairment leading to energy shortage, and c) oxidative stress, as a result of free radicals which are stable molecules missing one of their electrons.  PTSM bio-resonant signal  can spread into the CNS to enhance ATP production in the mitochondria.  It can donate electrons to the electron seeking free radicals hence turning them into stable molecules to reduce oxidative damage.  Reduced oxidative damage will allow for healthier DNA and proteins. PTSM key to lock bio-resonant waveform may be absorbed by the system and utilized in ion channels regulation which may play a central role in reversing neuro-degeneration and aging.  From this point of view ionic activity can be seen as a biological hub interconnecting a number of biological activities that are crucial in anti-aging as well as the maintenance of an optimal health status

DIABETES MELLITUS II
Individual phenotypic differences result in a variation of T4 to Free T3 conversion. Free T3 stimulates lipolysis. This leads to polymorphic and individualized lipid deposition patterns. Hyperthyroidism is associated with weight loss via an increase in metabolic rate and lipolysis. A  literature review  by Guillermo et al, (2003) has shown that the risk of thyroid dysfunction in Diabetic patients is two to threefold higher than in the general population. Although the benefits of intensified insulin treatment in insulin dependent Diabetes Mellitus are well recognized, a meta-analysis of 14 randomized controlled trials revealed the risk of severe Hypoglycemia, Ketoacidosis and mortality from acute metabolic causes with intensified insulin treatment. These 14 trails contributed 16 comparisons with 1028 patients allocated to intensified and 1039 allocated to conventional treatment. A total of 846 patients suffered at least one episode of severe hypoglycaemia, 175 patients experienced ketoacidosis and 26 patients died. We are investigating an alternative treatment for Diabetes with no side effects. This involves the enhancement of endogenous production of Free T3 and IGF-1 via the Pacemaker Technologye signal.
1. PTSM Initially targets the motor neurons resulting in rhythmical muscle contractions equivalent to performing high resistance physical activity. 2. Once the process is initiated, the motor neurons signal the brain  via  the spinal  cord. This  is  a  physiologically reversed process, where the strenuous exercise signal does not originate in the brain traveling down the spinal cord. Instead, the process is initiated at the peripheral motor neuron, then the circuit is completed by outgoing CNS neuron emission. 3. This CNS emission causes the ultimate production of Free T3 and GH/IGF-1, which in turn cause lipolysis and muscular hypertrophy. The enhanced production of Free T3 and GF/IGF-I will temporarily cause hyperglycemia which will resolve once the glucose has been utilized for metabolic purposes, energy increase
and muscular hypertrophy.

SUMMARY: Pacemaker Technology treatments appear beneficial in A. Muscle Building; B. Lipolysis; C. Anti-Aging; D. Erythrocyte Separation; E. Possibly Reducing the risk of Heart Disease; F. Reducing Oxidative Damage; F. Possibly Reducing the need for Statins; G. Possibly Reducing intolerance to Statins; H. Increasing ATP; I. Possibly Re-establishing Calcium Homeostasis.  J. Enhancing Secretion and Transport of Thyroid and Growth Hormones.

IONIC TECHNOLOGY AND DYNAMIC AGE REVERSAL:
According to the microscopic laws of physics, for every allowed process there exists a time-reversed process, a principle that applies to molecular biological events.  For example, Shanklin et al (2006) found that a single substitution in the amino acid sequence of an enzyme seemed to turn the clock 2.5 billion years back.
Endogenous ionic activity appears to be crucial in a number of key bio-molecular processes as well as life sustaining and reparative mechanisms:
1. Amino acids form proteins, being attracted to each other by virtue of their electrical charges.
2. Electrons turn the clock back by transforming free radicals into the stable molecules they were prior to oxidative damage.
3. Driven by the Proton Motive Force, ATPase rotates clockwise to produce ATP or anti-clockwise to break ATP down to ADP and a Phosphate.
4. DNA uses electrons to deflect oxidative damage away from its important sections.
5. The body is empowered by endogenous electrical fields to heal itself.
6. Ion Channels are involved in cell division and differentiation, initiation of immune responses and bio-electrochemical communication.
In conclusion, several life sustaining and time reversal processes appear to be electrical.

The single minded focus of this research group is to continue fine tuning ‘device — body’ communications on the basis of knowledge accumulated by the Pacemaker technology specializing in the unique interaction between electronic keys fitting biological lock mechanisms.

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